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建立国际上较为完整的皮肤病遗传资源库,收集储存了20 万份样本资源,致力于疾病遗传学和基因组学研究。致力于银屑病、白癜风、特应性皮炎、系统性红斑狼疮等皮肤科常见疾病的遗传学和基因组学研究,发现了这些常见疾病100 多个易感基因,揭示疾病部分遗传机制和遗传易感性,构建了中国汉族人群HLA区域大样本量的遗传图谱,为免疫相关疾病HLA区域的研究提供坚实的基础,系列研究取得多项有转化医学价值的系统性原创成果,为疾病机制研究提供了依据,为疾病治疗提供了新思路,在皮肤病遗传研究领域产生重要影响,对相近学科发展产生积极推动作用,对创立自主知识产权具有重要意义。为寻找新型药物靶点,完善疾病早期诊断体系和精确医疗方案,建立疾病预警和遗传咨询体系提供了依据。

基金支持:

1. 全基因组外显子测序搜寻中国汉族人银屑病易感基因,国家自然基金重点项目(81130031),2012.01-2016.12260

2. 系统性红斑狼疮易感基因外显子区编码变异的研究,国际(地区)合作与交流重大项目(81320108016)2014.01-2018.12280

3. 糖脂代谢相关基因多态性与皮肤遗传疾病的关联及发病机制研究,973计划研究专项(2012CB722404),2012.08-2014.12295

4. 皮肤病遗传学研究,国家自然基金优秀青年基金项目(81222022)2013.01-2015.12100

5. 靶向测序搜寻染色体20q13.33区域内特应性皮炎易感基因,国家自然科学基金面上项目(31171224),2012.01-2015.1260

6. 外显子测序搜寻特应性皮炎易感基因,教育部新世纪优秀人才(NCET-110889),2012.01-2014.1250

7. 5q22.1区域搜寻特应性皮炎易感基因研究,国家自然科学基金面上项目(81172838),2012.01-2015.1255

8. 全基因组外显子测序搜寻中国汉族人SLE易感基因,教育部新世纪优秀人才(NCET-120600),2013.01-2015.1250

8. 全基因组搜寻特异性皮炎的易感基因,国家自然科学基金面上项目(81071284),2011.01-2013.1234

9. 白癜风6q27区域易感基因搜寻,国家自然科学基金面上项目(81072460),2011.01-2013.1231

10. SLE易感基因和区域靶向测序研究,教育部科学技术研究项目(213018A),2013.10-2016.0920

代表性文章:

1. Zhang FR, Huang W, Chen SM, Sun LD, Liu H, Li Y, Cui Y, Yan XX, Yang HT, Yang RD, Chu TS, Zhang C, Zhang L, Han JW, Yu GQ, Quan C, Yu YX, Zhang Z, Shi BQ, Zhang LH, Cheng H, Wang CY, Lin Y, Zheng HF, Fu XA, Zuo XB, Wang Q, Long H, Sun YP, Cheng YL, Tian HQ, Zhou FS, Liu HX, Lu WS, He SM, Du WL, Shen M, Jin QY, Wang Y, Low HQ, Erwin T, Yang NH, Li JY, Zhao X, Jiao YL, Mao LG, Yin G, Jiang ZX, Wang XD, Yu JP, Hu ZH, Gong CH, Liu YQ, Liu RY, Wang DM, Wei D, Liu JX, Cao WK, Cao HZ, Li YP, Yan WG, Wei SY, Wang KJ, Hibberd ML, Yang S, Zhang XJ, Liu JJ. Genomewide association study of leprosy. New Engl J Med. Dec 2009;361(27):2609-18.

2. Zhang XJ, Huang W, Yang S, Sun LD, Zhang FY, Zhu QX, Zhang FR, Zhang C, Du WH, Pu XM, Li H, Xiao FL, Wang ZX, Cui Y, Hao F, Zheng J, Yang XQ, Cheng H, He CD, Liu XM, Xu LM, Zheng HF, Zhang SM, Zhang JZ, Wang HY, Cheng YL, Ji BH, Fang QY, Li YZ, Zhou FS, Han JW, Quan C, Chen B, Liu JL, Lin D, Fan L, Zhang AP, Liu SX, Yang CJ, Wang PG, Zhou WM, Lin GS, Wu WD, Fan X, Gao M, Yang BQ, Lu WS, Zhang Z, Zhu KJ, Shen SK, Li M, Zhang XY, Cao TT, Ren W, Zhang X, He J, Tang XF, Lu S, Yang JQ, Zhang L, Wang DN, Yuan F, Yin XY, Huang HJ, Wang HF, Lin XY, Liu JJ. Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet. 2009 Feb;41(2):205-10.

3. Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z, Xu JH, Cai ZM, Huang W, Zhao GP, Xie HF, Fang H, Lu QJ, Xu JH, Li XP, Pan YF, Deng DQ, Zeng FQ, Ye ZZ, Zhang XY, Wang QW, Hao F, Ma L, Zuo XB, Zhou FS, Du WH, Cheng YL, Yang JQ, Shen SK, Li J, Sheng YJ, Zuo XX, Zhu WF, Gao F, Zhang PL, Guo Q, Li B, Gao M, Xiao FL, Quan C, Zhang C, Zhang Z, Zhu KJ, Li Y, Hu DY, Lu WS, Huang JL, Liu SX, Li H, Ren YQ, Wang ZX, Yang CJ, Wang PG, Zhou WM, Lv YM, Zhang AP, Zhang SQ, Lin D, Li Y, Low HQ, Shen M, Zhai ZF, Wang Y, Zhang FY, Yang S, Liu JJ, Zhang XJ. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet. 2009 Nov;41(11):1234-7.

4. Sun L-D, Cheng H, Wang Z-X, Zhang A-P, Wang P-G, Xu J-H, Zhu Q-X, Zhou H-S, Ellinghaus E, Zhang F-R, Pu X-M, Yang X-Q, Zhang J-Z, Xu A-E, Wu R-N, Xu L-M, Peng L, Helms CA, Ren Y-Q, Zhang C, Zhang S-M, Nair RP, Wang H-Y, Lin G-S, Stuart PE, Fan X, Chen G, Tejasvi T, Li P, Zhu J, Li Z-M, Ge H-M, Weichenthal M, Ye W-Z, Zhang C, Shen S-K, Yang B-Q, Sun Y-Y, Li S-S, Lin Y, Jiang J-H, Li C-T, Chen R-X, Cheng J, Jiang X, Zhang P, Song W-M, Tang J, Zhang H-Q, Sun L, Cui J, Zhang L-J, Tang B, Huang F, Qin Q, Pei X-P, Zhou A-M, Shao L-M, Liu J-L, Zhang F-Y, Du W-D, Franke A, Bowcock AM, Elder JT, Liu J-J, Yang S, Zhang X-J. Association analyses identify six new psoriasis susceptibility loci in the Chinese population. Nat Genet 2010, 42(11): 1005-9.

5. Sun LD, Xiao FL, Li Y, Zhou WM, Tang HY, Tang XF, Zhang H, Schaarschmidt H, Zuo XB, Foelster-Holst R, He SM, Shi M, Liu Q, Lv YM, Chen XL, Zhu KJ, Guo YF, Hu DY, Li M, Li M, Zhang YH, Zhang X, Tang JP, Guo BR, Wang H, Liu Y, Zou XY, Zhou FS, Liu XY, Chen G, Ma L, Zhang SM, Jiang AP, Zheng XD, Gao XH, Li P, Tu CX, Yin XY, Han XP, Ren YQ, Song SP, Lu ZY, Zhang XL, Cui Y, Chang J, Gao M, Luo XY, Wang PG, Dai X, Su W, Li H, Shen CP, Liu SX, Feng XB, Yang CJ, Lin GS, Wang ZX, Huang JQ, Fan X, Wang Y, Bao YX, Yang S, Liu JJ, Franke A, Weidinger S, Yao ZR, Zhang XJ. Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population. Nat Genet. 2011; 43(7):690-4.

6. Tang HY, Jin X, Li Y, Jiang H, Tang XF, Yang X, Cheng H, Qiu Y, Chen G, Mei JP, Zhou FS, Wu RH, Zuo XB, Zhang Y, Zheng XD, Cai Q, Yin XY, Quan C, Shao HJ, Cui Y, Tian FZ, Zhao X, Liu H, Xiao FL, Xu FP, Han JW, Shi DM, Zhang AP, Zhou C, Li QB, Fan X, Lin LY, Tian HQ, Wang ZX, Fu HL, Wang F, Yang BQ, Huang SW, Liang B, Xie XF, Ren YQ, Gu QQ, Wen GD, Sun YL, Wu XL, Dang L, Xia M, Shan JJ, Li TH, Yang L, Zhang XY, Li YZ, He CD, Xu A, Wei LP, Zhao XH, Gao XH, Xu JH, Zhang FR, Zhang JZ, Li YR, Sun LD, Liu JJ, Chen RS, Yang S, Wang J, Zhang XJ. A large-scale screen for coding variants predisposing to psoriasis. Nature Genet. 2014;46(1):45-50.

7. Zhou F, Cao H, Zuo X, Zhang T, Zhang X, Liu X, Xu R, Chen G, Zhang Y, Zheng X, Jin X, Gao J, Mei J, Sheng Y, Li Q, Liang B, Shen J, Shen C, Jiang H, Zhu C, Fan X, Xu F, Yue M, Yin X, Ye C, Zhang C, Liu X, Yu L, Wu J, Chen M, Zhuang X, Tang L, Shao H, Wu L, Li J, Xu Y, Zhang Y, Zhao S, Wang Y, Li G, Xu H, Zeng L, Wang J, Bai M, Chen Y, Chen W, Kang T, Wu Y, Xu X, Zhu Z, Cui Y, Wang Z, Yang C, Wang P, Xiang L, Chen X, Zhang A, Gao X, Zhang F, Xu J, Zheng M, Zheng J, Zhang J, Yu X, Li Y, Yang S, Yang H, Wang J, Liu J, Hammarström L, Sun L, Wang J, Zhang X. Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease. Nat Genet. 2016 Jul;48(7):740-6.

8. Sheng Y, Jin X, Xu JH, Gao JP, Du XQ, Duan DW, Li B, Zhao JH, Zhan WY, Tang HY, Tang XF, Li Y, Cheng H, Zuo XB, Mei JP, Zhou FS, Liang B, Chen G, Shen CB, Cui HZ, Zhang XG, Zhang C, Wang WJ, Zheng XD, Fan X, Wang ZX, Xiao FL, Cui Y, Li YR, Wang J, Yang S, Xu L, Sun LD, Zhang XJ. Sequencing-based approach identified three new susceptibility loci for psoriasis. Nat Commun. 2014;5:6.

9. Zuo X, Sun L, Yin X, Gao J, Sheng Y, Xu J, Zhang J, He C, Qiu Y, Wen G, Tian H, Zheng X, Liu S, Wang W, Li W, Cheng Y, Liu L, Chang Y, Wang Z, Li Z, Li L, Wu J, Fang L, Shen C, Zhou F, Liang B, Chen G, Li H, Cui Y, Xu A, Yang X, Hao F, Xu L, Fan X, Li Y, Wu R, Wang X, Liu X, Zheng M, Song S, Ji B, Fang H, Yu J, Sun Y, Hui Y, Zhang F, Yang R, Yang S, Zhang X. Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis. Nat Commun. 2015 Apr 9;6:6793.

10. Yang W, Tang H, Zhang Y, Tang X, Zhang J, Sun L, Yang J, Cui Y, Zhang L, Hirankarn N, Cheng H, Pan HF, Gao J, Lee TL, Sheng Y, Lau CS, Li Y, Chan TM, Yin X, Ying D, Lu Q, Leung AM, Zuo X, Chen X, Tong KL, Zhou F, Diao Q, Tse NK, Xie H, Mok CC, Hao F, Wong SN, Shi B, Lee KW, Hui Y, Ho MH, Liang B, Lee PP, Cui H, Guo Q, Chung BH, Pu X, Liu Q, Zhang X, Zhang C, Chong CY, Fang H, Wong RW, Sun Y, Mok MY, Li XP, Avihingsanon Y, Zhai Z, Rianthavorn P, Deekajorndej T, Suphapeetiporn K, Gao F, Shotelersuk V, Kang X, Ying SK, Zhang L, Wong WH, Zhu D, Fung SK, Zeng F, Lai WM, Wong CM, Ng IO, Garcia-Barceló MM, Cherny SS, Shen N, Tam PK, Sham PC,Ye DQ, Yang S, Zhang XJ, Lau YL. Meta-Analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians. Am J Hum Genet. 2013 Jan 10;92(1):41-51.

带头人:孙良丹 教授

骨干成员:左先波、汤华阳、盛宇俊、王再兴

Copyrights 2012-2013 版权所有:安徽医科大学皮肤病研究所
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